Tiamulin                

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bulletChemical Structure
bulletChemical Formula
C32H51NO8S
bulletMolecular Weight:
609.8
bulletCas No.:
55297-96-6
bulletSynonyms
TIAMULIN HYDROGEN FUMARATE
bulletCompliance
 
bulletDescription

Semi-synthetic derivative of Pleuromutilin.

Appearance: White to yellowish crystal powder

bulletIndications
Tiamulin is extremely active against gram-positive organisms such as streptococci, staphylococci and against mycoplasmas and Serpulina (Treponema) hyodysenteriae. The range of values of Minimal inhibitory concentrations (MICs) against streptococci and staphylococci is between 0.015 and 0.15 µg/ml, with a few exceptions among Streptococcus faecalis strains. Tiamulin fumarate is particularly active against Serpulina hyodysenteriae, Leptospira spp., Mycoplasma spp., as well as many Gram positive and some Gram negative bacteria. Tiamulin is indicated for swine dysentery, swine enzootic pneumonia and chronic respiratory disease in poultry. Tiamulin is also useful in the prevention and treatment of pleuropneumonia caused by Actinobacillus pleuropneumoniae (APP). At low doses, tiamulin is an effective performance enhancer.

Tiamulin is a prokaryotic ribosome inhibitor that acts by blocking the initiation of polypeptide chain formation, thus preventing the synthesis of key enzymes and other proteins. Tiamulin is rapidly distributed in the body. The half-life in serum is several hours and virtually disappears within 24 hours. High concentrations of tiamulin are found in lung (target organ), liver and kidney (detoxifying organ); much lower concentrations are found in muscle and some other tissues. With ad libitum feeding tiamulin concentrations are maintained at a relatively steady-state. Following withdrawal of the medicine, tiamulin rapidly depletes from all organs and tissues. There is no accumulation of tiamulin in the blood or any organs or tissues following repeated or long-term administration of tiamulin-medicated feed.

The most interesting biological activity of Tiamulin, is its extreme effectiveness against mycoplasmas, surpassing such antibiotics as Tetracycline HCL and Tylosin tartrate which are considered the treatment of choice of these types of infections. The MIC values of Tiamulin against strains of mycoplasmas range from 0.004 to 6.25 µg/ml. Tiamulin acts bacteriostatically.

The serum concentration - time profile of Tiamulin after intramuscular injection is characterized by a rapid absorption phase, a short plateau phase and a long, slowly declining phase. Peak serum concentrations usually are reached within 1 hour after dosing, and concentrations in milk are considerably higher than in blood. T1/2 of the drug after im administration is about 3-6 h. Tiamulin is extensively metabolized in the liver (i.e. marker residue 8-a-hydroxymutilin).

The development of resistance to Tiamulin does not occur in one-step fashion, but becomes evident only after serial passage of sensitive bacteria on tiamulin-containing media.

In veterinary medicine Tiamulin is used for treatment, control and prophylaxis of swine dysentery, swine pneumonia and mycoplasmal diseases in pigs and poultry.

Comparisons of activities against field strains of Serpulina and Mycoplasma spp. show that tiamulin is one of the most active antibiotics. In addition, resistance development has not been a major problem. At low concentration, tiamulin has significant performance-enhancing activity and is effective in preventing development of disease, and at higher levels is very useful in treatment of the indicated diseases.

bullet Dosage
For the metaphylaxis of swine dysentery and enzootic pneumonia complex, fowl chronic respiratory disease and improvement in growth and feed efficiency, an inclusion rate of 25-30 ppm tiamulin fumarate in the diet is recommended. At this inclusion rate, no residues can be detected two days after withdrawal. For the treatment of swine dysentery and enzootic pneumonia complex and fowl chronic respiratory disease, an inclusion rate of 120 to 200 ppm tiamulin fumarate in the diet is recommended. At this inclusion rate, no residues can be detected five days after withdrawal
bulletStandards
Identification • IR-spectrum
• HPLC
pH 3.1 ~ 4.1
Loss on drying ≤1.0%

Heavy Metals

10 PPM

Content of Fumaric acid

≥18.6 ≤19.4

Purity HPLC ≥98%
bulletPacking
25 kg in double polyethylene bags in a fiber drum.
bulletStorage
In dry places, protected from direct sunlight, at a temperature of up to +25°C.
bulletExpiry
4 years.
bulletRemarks
In need of further information, please kindly us at: biok@vetamo.com or davidvan2000@hotmail.com or call our direct phone: 0086 133 5582 2008

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